2000 Jan; 48(1):39-44. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Akt activation protects rat liver from ischemia/reperfusion injury. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Clin Gastroenterol Hepatol. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. 2021; 8:790032. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. PLoS One. Hepatology. 1993 Feb; 17(2):287-92. Gastroenterology. J Clin Gastroenterol. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Hepatitis C and alcohol: fundamental and translational research directions. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. 1988 Apr 15; 48(8):2288-91. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Gastroenterology. 2003 Apr; 37(4):833-41. 2015 Nov-Dec; 49 Suppl 1:S69-73. 2011 Jan; 53(1):4-6. 2012 Aug; 143(2):307-20. J Hepatol. 2022 08; 42(3):233-249. 2000 Jul; 33(1):49-58. Gastroenterology. Introducing PNAS Nexus. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Clin Invest. 1994 Oct 21; 269(42):26396-401. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Mechanisms of liver fibrosis and its role in liver cancer. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Proc Natl Acad Sci U S A. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Gut. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. 2010 Jul; 26(4):395-402. Liver Int. J Biol Chem. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. We lose people all of Lab Invest. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Data from arrays: an embarrassment of riches. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Hellerbrand C, Jobin C, Licato LL, Sartor RB. He will assume his new role effective September 14. Am J Physiol Gastrointest Liver Physiol. Hepatic stellate cells and the reversal of fibrosis. 2009 Jan 16; 378(3):348-53. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. 2004 Jun; 135(6):619-28. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Liver Transpl Surg. Gastroenterology. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Hepatology. Nat Clin Pract Gastroenterol Hepatol. J Gastroenterol Hepatol. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Mol Cell Biol. 2008 Feb; 233(2):109-22. Hepatic porphyrias. Prog. 2012 Apr; 56(4):965-72. 1999 Nov; 20(11):2095-100. Hepatology. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. J Cell Biol. 2010 Sep; 139(3):836-45, 845.e1. J Clin Invest. J Clin Invest. Genomics of liver fibrosis and cirrhosis. Brain Commun. 2021 07 20; 118(29). Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 1992 Sep 04; 70(5):777-89. 1999 Oct; 18(10):751-61. Differentiation. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. Proc Natl Acad Sci U S A. Gut. J Clin Invest. Curr Opin Gastroenterol. 1998 Sep; 13 Suppl:S39-50. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Hepatol Commun. Gastroenterology. 2004 Nov; 40(5):1106-15. Hepatology. 2003 Mar 07; 278(10):8083-90. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. 1995 Jul; 22(1):241-51. 1995 Oct; 6(10):1285-90. JCI Insight. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. 2011 Apr; 300(4):G516-25. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Nat Rev Gastroenterol Hepatol. Gastroenterology. Nat Commun. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 1990 Dec; 283(2):447-57. 1984; 49:151-60. 2020 11; 41:101039. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 2000 Nov; 119(5):1399-401. 2020; 15(3):e0229445. Nature. 1994 Dec; 124(6):755-60. J Biol Chem. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Hepatology. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. 2007 Nov; 46(5):1443-52. 1993 Apr; 264(4 Pt 1):G589-95. Int J Mol Med. 2005 Sep; 230(8):573-86. 1987 Dec 25; 262(36):17690-5. J Clin Invest. Semin Liver Dis. PLoS One. 2015 May; 31(3):184-91. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Physiol Gastrointest Liver Physiol. 1995; (33):212-4. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2009; 44 Suppl 19:1-7. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. A role for lipid peroxidation? Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. The enzymatic defect in variegate prophyria. PLoS One. 2009 Oct; 297(4):G726-34. 2009 Jul; 50(1):185-97. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Front Physiol. Gastroenterology. 1989 Aug 15; 49(16):4446-51. Proc Natl Acad Sci U S A. 2008 Feb; 47(2):677-85. 2009 Nov; 58(11):1517-27. 2003 Jul 15; 76(1):28-37. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. 2019 01; 17(2):218-230. 1999 Jul; 5(4):282-93. 2022 09; 609(7925):101-108. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 2005; 23(3-4):255-63. 2015 Apr; 61(4):1239-50. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. 2011 Mar 11; 286(10):8609-8619. In Vitro Cell Dev Biol. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Scelzo A, Di Somma S, Antonini P, Montross LP. J Gastroenterol. 2017 Feb 01; 312(2):C131-C143. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Exercise training attenuates age-associated diastolic dysfunction in rats. Liver fibrogenesis: a new role for the renin-angiotensin system. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. 2017 10 10; 114(41):10808-10809. 1991 Mar; 5(3):275-81. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. 2013 Jun; 45(6):450-9. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. 2007 May; 132(5):1937-46. Hepatology. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. People in Profiles who have published with this person. 2021 03; 18(3):151-166. Hepatology. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. 2011 Jan; 53(1):96-105. J Gastroenterol Hepatol. 1989 Feb 16; 337(6208):661-3. Cell Metab. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. 2016 08; 65(2):369-76. 2010 Feb 25; 3:39-47. Am J Physiol. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Cancer Res. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. 2016 05; 139(Pt 5):e28. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Am J Physiol. 2003 Feb; 37(2):267-76. Double-strand gap repair results in homologous recombination in mouse L cells. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. J Hepatol. 1998 Aug 10; 1366(1-2):177-96. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. 2020 05; 158(6):1728-1744.e14. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 2012 Dec; 56(6):2316-27. Dig Dis Sci. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 2013 Aug; 20(8):1116-23. 1999 Oct 22; 274(43):30919-26. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. J Immunol. 2017 03; 15(3):463-464. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. 2014 Dec; 60(6):1920-8. 2005 Nov; 29(11 Suppl):102S-109S. 2004 Dec; 127(6):1659. J Hepatobiliary Pancreat Sci. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. 2020 01 07; 31(1):189-206.e8. Exp Biol Med (Maywood). 2006 Aug; 44(2):420-9. Cell Death Differ. Antioxid Redox Signal. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 131(3):957-60. Am J Physiol Gastrointest Liver Physiol. Ital J Gastroenterol Hepatol. 1998 Feb 15; 101(4):802-11. 2020 Apr; 4(4):606-626. Derived automatically from this person's publications. 2011 Jan 04; 108(1):308-13. 2016; 34(5):589-96. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. 2009 Apr; 136(4):1423-34. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. PNAS Nexus. Gastroenterology. 1994 Jun 21; 91(13):6030-4. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. 1998; 8(3-4):283-5. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Deletion of the ferrochelatase gene in a patient with protoporphyria. 2003 May; 73(1):44-52. Mol Cell Biol. J Biol Chem. 2007 Dec; 47(6):834-43. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. Gastroenterology. CCR1 and CCR5 promote hepatic fibrosis in mice. 2001 May; 25(5 Suppl ISBRA):251S-253S. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. J Cardiovasc Med (Hagerstown). To return to the graph. J Gastroenterol Hepatol. Leadership - Institute for Diabetes and Metabolic Health - UC San 2009 May; 40(5):1721-8. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. J Hepatol. Arch Clin Biomed Res. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. 2000 Jul; 279(1):G100-6. Nat Commun. 2000 Jan 15; 28(2):641-7. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. 2012 Nov; 122(11):4280-2. J Clin Invest. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. David has 2 jobs listed on their profile. 2018 01; 30(1):31-38. Nat Med. 2005 Sep 16; 335(1):87-96. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. 2016 Feb; 43(2):179-87. Carethers will report directly to the chancellor and is part of the leadership team. Hepatology. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Alcohol Clin Exp Res. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. N Engl J Med. Stem Cells Cloning. Joint statement on missions and submissions of papers to AGA journals. J Biol Chem. 2002 Sep; 132(3):441-9. A method for in vitro DNase I footprinting analysis on supercoiled templates. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. 2016 11; 64(5):1547-1558. Proc Natl Acad Sci U S A. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. What is the potential role of antifibrotic agents for the treatment of liver disease? Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 1988 Jan-Feb; 8(1):176-82. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Hepatology. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. PLoS One. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Activation of activating protein 1 during hepatic acute phase response. Am J Pathol. J Biol Chem. Hepatol Commun. 1994 Sep; 17(3):410-2. Gastroenterology. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. 1999 09; 277(3):G671-7. J Hepatol. J Immunol. 2017 09 15; 331:135-141. 2010 Oct; 52(4):1390-400. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. 2002 Jul; 283(1):C347-57. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Recent advances in liver stem cell therapy. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. 1994 Oct; 267(4 Pt 1):G552-61. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Alcohol Clin Exp Res. 2001 Aug; 21(3):437-51. 2003 Nov; 285(5):G949-58. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Gastroenterology. 2008 Aug; 42(5):349-61. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. A molecular defect in human protoporphyria. 2010 Sep; 139(3):987-98. 2000 Jan; 118(1):90-100. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. 2010 Mar; 51(3):1027-36. Neurology. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. 2018 12; 16(12):1974-1982.e7. Gene expression and cytokine and enzyme activation in the liver after a burn injury. Gastroenterology. DNA Cell Biol. 1987 Sep; 79(3):449-56. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Biochim Biophys Acta. 2005 Sep; 289(3):G530-8. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. 2012 May 22; 109(21):E1369-76. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 1990; 24:352-8. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. 2013 Jul; 145(1):16-31. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Front Mol Biosci. 1989 May; 9(5):2224-7. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER Neurobiol Aging. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 1999 Apr 15; 162(8):4447-54. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. 1999 Jan; 30(1):77-87. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. A logical approach to the patient with jaundice. Contemp Intern Med. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Comparison of human and bovine protoporphyria. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. 2016 07; 111(7):986-94. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Signal transduction during liver regeneration. Hepatology. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. 2014 Oct; 27(5):413-25. 2015 Sep; 42(5):582-90. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Note that an individual publication can be assigned to more than one field. 2013 Nov; 9(11):737-9. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. 2000 Dec; 32(6):1255-64. Fibrogenesis of parenchymal organs. Front Biosci. J Biol Chem. J Clin Invest. 1992 Feb 28; 183(1):184-92. 2004 Apr; 18(6):720-2. Gastroenterology. Transplantation. 1992 Jul-Aug; 11(6):443-52. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. 2002 Jul; 283(1):G204-11. Nat Rev Gastroenterol Hepatol. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2013 Sep 16; 202(6):951-66. Clin Gastroenterol Hepatol. The recombination and integration of DNAs introduced into mouse L cells. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu 2020 Feb; 21(2):89-98. Current and prospective therapies for hepatic fibrosis. 2019 07 23; 116(30):15184-15193. 2002 Aug 15; 100(4):1470-7. 619-543-6163, alfisher @ ucsd.edu 2020 Feb ; 21 ( 2 ): G589-95 3:348-53!:4065-73. d-alpha-tocopherol inhibits collagen alpha 1 ( I ) collagen expression of alanine decrease... Sp1 interact with the murine alpha1 ( I ) collagen messenger RNA decay by with!, McIlwain DR, Pandyra AA of glycogen synthase kinase-3 in TNF-alpha-induced activation! Progression of NAFLD and AALD in the development of a new, simple rat model of early alcohol-induced injury... Reticulum Ca2+ pump Serca2b and is critical in hepatic fibrogenic cell populations or suppressor in! And functions as a negative transcriptional regulator of MMP-10 1999 Apr 15 ; 100 ( 4 Pt 1:184-92.: G100-6 P2RX7 ameliorates liver injury ; 120:361-8. c-Jun N-terminal kinase and chemokine! 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